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目的:了解降压药物的临床应用情况,探讨降压药物临床用药的特点、选用规律、倾向及合理性。方法:抽取某三甲医院2008年1～11月的第一诊断为原发性高血压住院病历310份,对患者的临床特点、使用降压药物的影响因素进行统计分析。结果:极高危患者最多,占95.16%。大多数患者有合并症。药物使用频率较高的是钙拮抗药,其次是血管紧张素Ⅱ受体阻断药和β-受体阻断药。大部分联合用药,占91.94%。降压药物使用受患者个体状况、药物作用特点、不良反应、相互作用、循证医学证据等多种因素影响。结论:该院降压药物使用注重个体化原则,使用基本合理,与指南相符。
Objective: To understand the clinical application of antihypertensive drugs, to explore the characteristics of clinical drug antihypertensive drugs, selection rules, tendencies and rationality. Methods: The first diagnosis from January to November 2008 in a top three hospital was collected from 310 hospitalized patients with essential hypertension. The clinical characteristics of patients and the influencing factors of using antihypertensive drugs were statistically analyzed. Results: The most high-risk patients, accounting for 95.16%. Most patients have comorbidities. Drugs with higher frequency of calcium antagonists, followed by angiotensin Ⅱ receptor blockers and β-blockers. Most combined medication, accounting for 91.94%. The use of antihypertensive drugs is influenced by many factors such as patient’s individual status, drug action characteristics, adverse reactions, interactions and evidence-based medical evidence. Conclusion: The hospital use of antihypertensive drugs focus on individual principles, the use of basic and reasonable, in line with the guidelines.