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许多实验室对一系列化学结构相关化合物的致突变性进行了研究,在这种结构与活性关系的研究中,沙门氏菌/哺乳动物肝微粒体试验(Ames试验)是应用得最为广泛的致突变性测试系统。因此,本文重点研究分析纯品化学物质所得到的Ames试验结果。在报道致癌性结果时,作者首先研究国家癌症研究所(NCI)的致癌作用技术报告丛书和国际癌症研究机构(IARC)发表的化学物质对人类致癌危险性的专论。只是在得不到NCI或IARC评价时,才使用其它有关致癌作用的文献资料,或者是后者研究的时间比NCI或IARC的研究更为
Many laboratories have studied the mutagenicity of a series of chemical structure-related compounds. In this study, the Salmonella / mammal liver microsomal assay (Ames test) is the most widely used mutagenicity Test system. Therefore, this article focuses on the analysis of pure chemicals obtained Ames test results. In reporting carcinogenicity results, the authors first studied the National Cancer Institute’s (NCI) Carcinogenicity Technical Report series and the monograph on the carcinogenicity of humans to humans published by the International Agency for Research on Cancer (IARC). Only other literature on carcinogenesis is used when NCI or IARC evaluation is not available or the study is more time-consuming than either NCI or IARC