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[目的]探讨晚期卵巢癌的治疗方法。[方法]采用Seldinger法经一侧股动脉穿刺行超选择动脉插管化疗晚期卵巢癌81例。第一组50例包括首次手术困难仅行活检明确病理诊断31例或部分肿瘤切除术19例。第二组31例包括首次手术已行全子宫双附件切除18例及13例复发性卵巢癌。分析治疗效果与副反应。[结果]经SIAC治疗,肿瘤体积明显缩小,粘连程度减轻,胸腹水减少,第一组效果比第二组显著。总的生存率升高,半年、2年、5年生存率分别为92. 6%、57. 4%、13.6%,第一组生存率分别为98.0%、62. 3%、21.6%,明显高于第二组(80.6%、50.0%、0)。[结论]超选择动脉插管化疗是一种有效治疗晚期卵巢癌的方法,对第一次手术困难者,先仅活检后行动脉插管化疗,可为彻底手术创造条件,提高患者生存率。
[Objective] To investigate the treatment of advanced ovarian cancer. [Method] Seldinger ’s method was used to treat 81 cases of advanced ovarian cancer by superselective arterial catheterization through one femoral artery puncture. The first group of 50 cases included only the first surgical difficulties biopsy clear pathological diagnosis of 31 cases or partial tumor resection in 19 cases. The second group of 31 cases including the first operation of the total hysterectomy double attachment resection in 18 cases and 13 cases of recurrent ovarian cancer. Analysis of treatment and side effects. [Result] After treatment with SIAC, the volume of tumor was significantly reduced, the degree of adhesion was relieved, and pleural and ascitic fluid were reduced. The effect of the first group was more significant than that of the second group. The overall survival rate increased, six months, two years, five-year survival rates were 92. 6%, 57. 4%, 13.6%, the first group survival rates were 98.0%, 62. 3%, 21.6%, significantly higher than the second group (80.6%, 50.0%, 0). [Conclusion] Superselective arterial intubation chemotherapy is an effective method for the treatment of advanced ovarian cancer. Arterial intubation and chemotherapy after the first biopsy can create conditions for radical surgery and improve patient survival rate.