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目的:观察周剂量紫杉醇联合卡铂治疗晚期非小细胞肺癌的近期疗效和毒副反应。方法:晚期非小细胞肺癌患者25例,治疗方案为:紫杉醇80 m g/m2,卡铂(曲线下面积为2)第1、8、15天给药,4周为1个周期,共6个周期,根据患者的毒性反应调整剂量及疗程,至少治疗2周期评价疗效。结果:CR 2例,PR 15例,NC 4例,PD 4例。紫杉醇的总有效率为68%(17/25)。主要毒副反应为血液学毒性,血液学毒性主要为白细胞减少,多为Ⅰ~Ⅱ度,共7例,占28%;Ⅲ度1例,占4%;Ⅳ度0例,占0%。血红蛋白下降2例(8%),血小板下降3例(12%),均为Ⅰ~Ⅱ度。非血液学毒性较轻微。无化疗相关性死亡。结论:周剂量紫杉醇联合卡铂方案治疗晚期非小细胞肺癌疗效好,毒副反应轻。
Objective: To observe the short-term curative effect and toxicity of paclitaxel combined with carboplatin in the treatment of advanced non-small cell lung cancer. Methods: Twenty-five patients with advanced non-small cell lung cancer were treated with paclitaxel 80 mg / m2, carboplatin (area under the curve 2) on days 1, 8 and 15, and 1 cycle for 4 weeks Cycle, adjust the dose and course of treatment according to the patient’s toxicity response, at least the treatment of 2 cycles to evaluate the efficacy. Results: CR 2 cases, PR 15 cases, NC 4 cases, PD 4 cases. The total effective rate of paclitaxel was 68% (17/25). The main toxicities were hematological toxicity. The main hematological toxicities were leukopenia, mostly grade Ⅰ ~ Ⅱ, with a total of 7 cases, accounting for 28%. Grade Ⅲ was 1 case, accounting for 4%. Grade Ⅳ was 0 case, accounting for 0%. Hemoglobin decreased in 2 cases (8%), thrombocytopenia in 3 cases (12%), were Ⅰ ~ Ⅱ degrees. Non-hematologic toxicity is minor. No chemotherapy-related death. Conclusion: The weekly dose of paclitaxel combined with carboplatin in the treatment of advanced non-small cell lung cancer has good curative effect and light toxicity.