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系膜增生性肾炎(mesangial proliferative glomerulonephritis,MsPGN)是一组病理上以弥漫性肾小球系膜细胞(MC)增生、肾小球基底膜(GBM)增厚及不同程度肾小球系膜区细胞外基质(ECM)积聚为主要特征的肾小球疾病。MsPGN为我国原发性肾小球疾病中最常见的病理类型,国内资料显示该型约占原发性肾小球疾病肾活检病例的20.3%～24.7%。若未采取有效治疗,最终导致不可逆性肾小球硬化。中药治疗MsPGN具有较好疗效,并且可以减少复发,其中益气化瘀之品黄芪、水蛭是最常用的治疗药物。传统认为MsPGN以气虚等本虚为本,血瘀等邪实为标,但临床上血瘀似乎占有更重要的地位,活血化瘀几乎是治疗MsPGN的基本方法。
Mesangial proliferative glomerulonephritis (mesangial proliferative glomerulonephritis, mesangial proliferative glomerulonephritis (mesangial proliferative glomerulonephritis, is a group of pathological diffuse glomerular mesangial cells (MC) hyperplasia, glomerular basement membrane (GBM) thickening and varying degrees of mesangial area Extracellular matrix (ECM) accumulation is a major feature of glomerular disease. MsPGN is the most common pathological type of primary glomerular disease in our country. Domestic data show that this type accounts for 20.3% ~ 24.7% of primary renal glomerular disease cases. Failure to take effective treatment ultimately leads to irreversible glomerulosclerosis. Chinese medicine treatment of MsPGN has a good effect, and can reduce the recurrence, of which astragalus, leech is the most commonly used therapeutic drugs. The traditional view that MsPGN is based on the deficiency of the Qi and so on, and blood stasis and other evil as the standard, but clinical blood stasis seems to occupy a more important position, blood circulation is almost the basic method of treatment of MsPGN.