论文部分内容阅读
目的研究轮状病毒肠炎（ＲＶＥ）患儿血清中免疫球蛋白（Ｉｇ）和Ｔ细胞亚群的动态变化及其临床意义。方法采用透射比浊法和抗体致敏红细胞花环试验检测了３８例生长发育正常的ＲＶＥ患儿血清Ｉｇ和Ｔ细胞亚群。结果急性期血清ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值明显低于对照组及恢复期（Ｐ＜０．０１），尤其是ＩｇＡ、ＣＤ４／ＣＤ８比值较对照组降低更为明显（Ｐ＜０．００１），ＣＤ８明显高于对照组及恢复期（Ｐ＜０．０１）。随着临床症状逐渐消失，恢复期ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４及ＣＤ４／ＣＤ８比值升高，ＣＤ降低并逐渐恢复正常，与对照组之间比较无显著性差异（Ｐ＞０．０５）。结论细胞免疫和体液免疫功能参与了ＲＶ的感染过程，ＩｇＡ、ＣＤ４／ＣＤ８比值与疾病的预后有关
Objective To study the dynamic changes of serum immunoglobulin (Ig) and T cell subsets in children with rotavirus enteritis (RVE) and its clinical significance. Methods The serum Ig and T cell subsets of 38 RVE children with normal growth and development were detected by transmission turbidimetry and antibody-sensitized erythrocyte rosette. Results The serum levels of IgG, IgA, IgM, CD3, CD4 and CD4 / CD8 in acute stage were significantly lower than those in control group and convalescence stage (P <0.01), especially the ratio of IgA and CD4 / P <0.001), CD8 was significantly higher than the control group and convalescence (P <0.01). With the gradual disappearance of clinical symptoms, the ratio of IgG, IgA, IgM, CD3, CD4 and CD4 / CD8 in recovery period increased, CD decreased and returned to normal gradually. There was no significant difference between the two groups (P> 0.05) . Conclusions Cellular immunity and humoral immune function are involved in the process of RV infection. The ratio of IgA and CD4 / CD8 is related to the prognosis of the disease