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非固醇类的抗炎药物广泛用于治疗风湿病、关节病和肾病,它们的作用机理很复杂,其抗炎作用与炎症递质(组织胺、5-羟色胺、缓激肽)直接拮抗有关。在用这类药物时发现,炎症灶内白细胞游走受到限制、白细胞的吞噬功能下降。现有报道,消炎痛具有免疫抑制作用,水杨酸类和吡唑衍生物能抑制抗原-抗体反应。但是的作用机理在很大程度上取决于它们对前列腺素(PG)系统的影响。人们认为,PG在引起和维持炎症过程中具有重要意义。所有的都是PG的抑制剂,按其对PG抑制程度,甲灭酸>消炎痛>>保泰松>阿斯匹林。但是对于机体每个器官来说,它们之间的作用亦有差异,如对肾PG,
Non-steroidal anti-inflammatory drugs are widely used in the treatment of rheumatism, arthrosis and nephropathy. Their mechanism of action is complex and their anti-inflammatory effects are directly antagonized by the inflammatory mediators (histamine, serotonin, bradykinin) . In the use of such drugs found that inflammatory lesions within the leukocyte migration is restricted, the phagocytic function of leukocytes decreased. It has been reported that indomethacin has an immunosuppressive effect. Salicylates and pyrazole derivatives can inhibit the antigen-antibody reaction. But the mechanism of action depends largely on their effect on the prostaglandin (PG) system. It is thought that PG plays an important role in causing and sustaining inflammation. All are PG inhibitors, according to their degree of inhibition of PG, mefenamic acid> indomethacin >> phenylbutazone> aspirin. But for each organ of the body, the role of them also have differences, such as kidney PG,