Synthesis of organophosphoms derivatives of 2-aminoglucopyranose and their antitumor activities

• 作 者: 陈茹玉 陈小茹 毛丽娟
• 机 构: InstituteofElemento-OrganicChemistry
• 出 处: Science in China(Series B)
• 发表日期: 1995年7期
• 关键词: isomers tetra substituted deoxy acetyl subsequent antitumor inhib chiral methoxy

A series of novel N-[（p-substituted phenyl）dialkoxyphosphoryl]methyl-2-amino-2-deoxy-1,3,4,6-tetra-O-acetyl-β-D-glucopyranose 4 were synthesized by the addition reaction of the imines 3 with the phosphites.And through subsequent alcoholysis of compounds 4