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目的:通过观察慢性心功能不全(CCD)患者外周血浆尾加压素Ⅱ(UⅡ)与N端脑钠肽前体(NT-proBNP)变化,探讨尾加压素在CCD中的临床意义。方法:分别选择90例CCD患者和健康对照组20人。所有研究对象于入院时即刻抽静脉血行常规检查以及分离血浆待检UⅡ及NT-proBNP,并行超声心动图检测左室射血分数(LVEF)。分析血浆UⅡ、NT-proBNP以及LVEF在CCD中的变化和三者间的相关性。结果:CCD患者血浆NT-proBNP明显升高(P<0.01),血浆UⅡ水平明显降低(P<0.01),NT-proBNP、UⅡ浓度以及LVEF三者间明显相关(P<0.01)。结论:UⅡ可以反映CCD的严重程度。
Objective: To investigate the clinical significance of urotensin in CCD by observing the changes of urotensin Ⅱ (UⅡ) and NT-proBNP in peripheral blood of patients with chronic heart failure (CCD). Methods: 90 patients with CCD and 20 healthy controls were selected. All subjects were admitted to hospital immediately pumping venous blood routine examination and separation of plasma U Ⅱ and NT-proBNP, parallel echocardiography detection of left ventricular ejection fraction (LVEF). The changes of plasma UⅡ, NT-proBNP and LVEF in the CCD were analyzed and their correlations were analyzed. Results: The plasma NT-proBNP level was significantly higher in patients with CCD (P <0.01), while plasma UⅡ level was significantly lower (P <0.01). There was a significant correlation between NT-proBNP, UⅡ concentration and LVEF (P <0.01). Conclusion: UII can reflect the severity of CCD.