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目的观察纳洛酮联合氨茶碱在早产儿原发性呼吸暂停中的应用疗效及其安全性。方法将48例生后发生原发性呼吸暂停的早产儿,随机分成对照组和治疗组各24例。治疗组在综合治疗的基础上给予纳洛酮联合氨茶碱交替使用,对照组则在综合治疗的基础上给予氨茶碱常规应用。结果治疗组显效率和总有效率为79.16%(19/24)和95.83%(23/24),对照组分别为41.67%(10/24)和66.67%(16/24)。二组患者治疗效果差异有统计学意义(P<0.01)。结论纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停疗效显著优于常规单独应用氨茶碱治疗。
Objective To observe the efficacy and safety of naloxone combined with aminophylline in the treatment of premature infants with primary apnea. Methods Forty-eight premature infants with primary apnea after birth were randomly divided into control group and treatment group with 24 cases each. The treatment group was given naloxone combined with aminophylline on the basis of comprehensive treatment, while the control group was given routine aminophylline treatment on the basis of comprehensive treatment. Results The effective rate and total effective rate in the treatment group were 79.16% (19/24) and 95.83% (23/24), respectively, while those in the control group were 41.67% (10/24) and 66.67% (16/24) respectively. The difference between the two groups was statistically significant (P <0.01). Conclusion Naloxone combined with aminophylline in the treatment of premature children with primary apnea was significantly better than the conventional treatment with aminophylline alone.