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目的:观察辅舒酮吸入配合小青龙汤对哮喘患者肺功能和血清IL-16的影响。方法:选择中、重度哮喘发作期患者54例,随机分为3组。治疗组:辅舒酮吸入配合小青龙汤口服;辅舒酮组:单纯辅舒酮吸入;小青龙汤组:单纯口服小青龙汤。治疗前和治疗4周后测定肺通气功能FEV_1和呼吸阻抗R_5,用酶联免疫吸附法测定血清白细胞介素-16(IL-16)的水平。另选10例健康志愿者作为对照组。结果:治疗后3组患者肺通气功能FEV_1均显著增加、呼吸阻抗R_5均显著减少(P<0.05或P<0.01),但以治疗组改善最为明显(P<0.01)。治疗前3组IL-16水平均显著高于健康对照组(P<0.01),治疗后各组IL-16水平明显下降(P<0.05或P<0.01),以治疗组下降最为明显(P<0.01)。血清IL-16含量分别与FEV_1、R_5值呈负相关和正相关(r_1=-0.67,r_2=0.71,P均<0.01)。结论:辅舒酮吸入配合口服小青龙汤对哮喘患者肺功能改善和抑制血清IL-16的作用,明显优于单纯吸入辅舒酮或单纯口服小青龙汤,可成为中、重度哮喘的重要治疗手段。
OBJECTIVE: To observe the effects of combination of Fuzheng ketone with Xiaoqinglong decoction on pulmonary function and serum IL-16 in asthmatic patients. Methods: Fifty-four patients with moderate and severe asthma attack were randomly divided into three groups. Treatment group: Fuxu ketone inhalation with Xiao Qinglong decoction oral; Fu Qulong group: Fuxu ketone inhalation alone; Xiao Qinglong soup group: simple oral Xiaoqinglong Tang. Before treatment and after 4 weeks of treatment, pulmonary ventilatory function (FEV 1) and respiratory resistance (R_5) were measured. Serum interleukin-16 (IL-16) levels were measured by enzyme-linked immunosorbent assay. Another 10 healthy volunteers as a control group. Results: After treatment, pulmonary ventilation function FEV_1 in all three groups increased significantly and respiratory resistance R_5 decreased significantly (P <0.05 or P <0.01), but the improvement in the treatment group was the most obvious (P <0.01). The levels of IL-16 in the three groups before treatment were significantly higher than those in the healthy control group (P <0.01), and the levels of IL-16 in each group were significantly decreased after treatment (P <0.05 or P <0.01) 0.01). Serum IL-16 levels were negatively correlated with FEV_1 and R_5, respectively (r_1 = -0.67, r_2 = 0.71, P <0.01). Conclusion: The combination of Fuketoketone and oral Xiao Qing Long Decoction can improve pulmonary function and inhibit the serum IL-16 in asthmatic patients, which is obviously better than inhalation of FuQurong or oral XiaoQingLong Decoction alone, which may be an important treatment for moderate and severe asthma means.