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用高脂血症大鼠模型研究了油茶皂甙的调脂作用。血清高密度脂蛋白胆固醇（ＨＤＬ）及其亚组分３（ＨＤＬ３）用聚乙二醇２００００法分离，血脂用酶法测定。实验结果显示油茶皂甙能明显降低血清总胆固醇（ＴＣｈ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ）和ＨＤＬ３，不显著改变ＨＤＬ浓度，轻微升高ＨＤＬ亚组分２（ＨＤＬ２），降低动脉硬化指数（ＡＩ）。在１００ｍｇ／ｋｇ以内时，油茶皂甙降低ＴＣｈ、ＴＧ、ＬＤＬ、ＡＩ，升高ＨＤＬ２／ＨＤＬ３比值存在明显量效关系。５０至１００ｍｇ／ｋｇ时油茶皂甙降脂作用强度相当于氯贝丁酯２５０ｍｇ／ｋｇ。
The hyperlipidemic rat model was used to study the lipid-regulating effect of Camellia saponins. Serum high-density lipoprotein cholesterol (HDL) and its sub-component 3 (HDL3) were separated using polyethylene glycol 20000 and the lipids were measured enzymatically. The results showed that Camellia saponin could significantly reduce the levels of total cholesterol (TCh), triglyceride (TG), low density lipoprotein cholesterol (LDL) and HDL3 without significantly changing the concentration of HDL and slightly increasing HDL subunit 2 (HDL2) , Reduce atherosclerosis index (AI). Within 100mg / kg, there was a significant dose-response relationship between the content of TCh, TG, LDL, AI and the increase of HDL2 / HDL3 ratio. 50 to 100mg / kg Camellia saponins lipid-lowering effect of the intensity equivalent of clofibrate 250mg / kg.