促红细胞生成素及经静脉注射的铁剂处理肾源性系统性纤维化大鼠

• 作 者: T.A.Hope W.A.High P.E.Leboit B.Chaopathomkul V.S.Rogut R.J.Herfkens 史晓喆
• 机 构: Department of Radiology,University of California San Francisco,
• 出 处: 国际医学放射学杂志
• 发表日期: 2010年01期
• 关键词: 肾源性 铁剂 大鼠 钆双胺 联合用药 细胞结构 对比剂 组织学检查 损害比 大体标本

目的本实验对静脉给予高剂量钆双胺建立的肾源性系统性纤维化大鼠模型予以促红细胞生成素(Epo)及静脉铁剂联合用药,观察用药后大鼠的皮肤损害可能发展的程度,这种皮肤损害被认为是肾源性系统性纤维化病变发展的标志

Objective In this experiment, a rat model of nephrogenic systemic fibrosis established by intravenous administration of high dose of gadodiamide was administered with erythropoietin (Epo) and intravenous iron agents to observe the possible development of the skin lesions in rats This skin lesion is considered a hallmark of the development of nephrogenic systemic fibrosis