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目的研究普通人群中正常SUA与非酒精性脂肪性肝病(NAFLD)的关系。方法收集22209例正常SUA体检者的临床和生化资料并通过腹部B超诊断NAFLD。按照是否存在NAFLD分为非NAFLD(Non-NAFLD)组和NAFLD组,按照性别特异的SUA四分位数分为4组(Q1~Q4)。结果本研究人群中NAFLD的患病率为20.9%。随着SUA水平升高,各组年龄、BMI、SBP、DBP、TG、TC、LDL-C、Scr、谷丙转氨酶(ALT)和谷草转氨酶(AST)均升高,而HDL-C降低(P<0.001);Q1组至Q4组,NAFLD患病率逐渐升高(分别为12.3%、16.0%、23.0%和32.6%,P<0.001);校正性别、年龄、BMI、血压、血脂后,多元Logistic回归分析显示,Q2~Q4组NAFLD患病风险较Q1组分别增加24%、43%和94%(P<0.001)。结论普通人群正常范围内SUA的升高与NAFLD密切相关,可能是其发生的独立危险因素。
Objective To investigate the relationship between normal SUA and nonalcoholic fatty liver disease (NAFLD) in the general population. Methods The clinical and biochemical data of 22,209 normal SUA subjects were collected and NAFLD was diagnosed by abdominal ultrasonography. Patients were divided into 4 groups (Q1 to Q4) according to gender-specific SUA quartiles according to the presence or absence of NAFLD in non-NAFLD group and NAFLD group. Results The prevalence of NAFLD in this study population was 20.9%. With the increase of SUA level, the levels of BMI, SBP, DBP, TG, TC, LDL-C, Scr, ALT and AST were all increased, while the levels of HDL- <0.001). The prevalences of NAFLD increased from Q1 to Q4 (12.3%, 16.0%, 23.0%, and 32.6% respectively, P <0.001). After adjustment for sex, age, BMI, blood pressure, Logistic regression analysis showed that the risk of NAFLD in Q2 ~ Q4 group increased by 24%, 43% and 94% respectively (P <0.001) compared with Q1 group. Conclusions The elevation of SUA in normal population is closely related to NAFLD, which may be an independent risk factor for its occurrence.