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双膦酸盐类药物是在近二十年来发展并逐渐得到了广泛运用的一种抗代谢性骨病新药,主要是用在骨痛症与高钙血症患者的治疗中。双膦酸盐类药物能够对骨的羟基磷灰石结晶表现出特意的亲和力,可以在羟磷灰石的表面进行紧密的附着,但是却不会被骨的焦磷酸酶降解,这也就是双膦酸盐类药物在临床中得到广泛应用的基础。本文现以双膦酸盐类药物为研究对象,分析了双膦酸盐类药物在临床应用中的进展,对其常见的临床应用以及不良反应进行了分析,以期能够为临床合理应用双膦酸盐类药物提供借鉴。
Bisphosphonates, a new antimetabolite osteodystrophy developed over the past two decades and gradually gaining in popularity, are mainly used in the treatment of patients with bone pain and hypercalcaemia. Bisphosphonates exhibit a specific affinity for bone hydroxyapatite crystals that adhere closely to the surface of hydroxyapatite but are not degraded by bone pyrophosphatase, Phosphonate drugs are widely used in clinical practice. In this paper, bisphosphonates as the research object, analysis of bisphosphonates in the clinical application of the progress of its common clinical applications and adverse reactions were analyzed in order to be able to clinically rational use of bisphosphonic acid Salt drugs to provide reference.