论文部分内容阅读
以β-二硫代二丙酸二甲酯和烯丙基胺为原料,通过酰胺化反应合成了N,N′-二烯丙基二硫代二丙酰胺(ALPD),用红外光谱和核磁共振氢谱对ALPD结构进行了表征。探讨了反应物摩尔比、催化剂用量、β-二硫代二丙酸二甲酯滴加时间、反应时间对ALPD产率的影响;考察了ALPD的抑菌性能。结果表明,烯丙基胺为0.3mol,n(烯丙基胺)∶n(β-二硫代二丙酸二甲酯)=3∶1,催化剂三乙胺为2.5 mL,β-二硫代二丙酸二甲酯的滴加时间为2.5 h,反应时间为48 h,产率为88.4%。ALPD对大肠杆菌、金黄色葡萄球菌的最小抑菌质量浓度分别为0.125 0、0.062 5 g/L。ALPD中的双键可以通过聚合反应引入到大分子结构中。
N, N’-diallyldithiopropionamide (ALPD) was synthesized by amidation reaction using dimethyl β-dithiodipropionate and allyl amine as raw materials. Resonance hydrogen spectra of ALPD structure was characterized. The effects of molar ratio of reactants, amount of catalyst, dimethyl-β-dithiodipropionate dropping time and reaction time on the yield of ALPD were investigated. The antibacterial activity of ALPD was also investigated. The results showed that allyl amine was 0.3mol, n (allylamine): n (dimethyl β-dithiodipropionate) = 3:1, catalyst triethylamine was 2.5 mL, β-dithio Dimethyl dioleate was added dropwise for 2.5 h, the reaction time was 48 h, the yield was 88.4%. The minimum inhibitory concentrations of ALPD against Escherichia coli and Staphylococcus aureus were 0.125 0,0.062 5 g / L, respectively. Double bonds in ALPD can be introduced into the macromolecular structure through polymerization.