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运用吖啶橙（AO）／溴乙锭（EB）染色法检测阿糖胞苷（Ara－c）、高三尖杉酯碱（HHT）体外诱导临床初发及复发／难治急性非淋巴细胞白血病（ANLL）患者的白血病细胞凋亡，观察细胞凋亡指数与临床疗效的关系。结果显示初治ANLL药物诱导组凋亡率明显高于复发／难治组，初治组完全缓解（CR）者凋亡指数明显高于未缓解（NR）者。说期凋亡与耐药、凋亡与临床疗效有一定的关系。
Acridine orange (AO)/ethidium bromide (EB) staining was used to detect Ara-c and homoharringtonine (HHT) in vitro induction of clinical primary and relapsed/refractory acute nonlymphocytic leukemia (ANLL) The patient’s leukemia cell apoptosis, observe the relationship between apoptosis index and clinical curative effect. The results showed that the apoptosis rate of the initial treatment group was significantly higher than that of the relapsed/refractory group. The apoptotic index of the complete remission (CR) group was significantly higher than that of the untreated (NR) group. There is a certain relationship between apoptosis and drug resistance, apoptosis and clinical efficacy.