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HBV外膜蛋白是HBV颗粒的外膜组成部分,是决定病毒吸附至易感细胞受体的成分,编码包膜蛋白的基因分为前S1、前S2及S三个编码区,分别编码前S1蛋白、前S2蛋白及HBsAg。HBsAg是一种跨膜糖蛋白,在HBV感染时大量释放到患者血清中。自从1965年Blumberg发现HBsAg用于诊断HBV感染并获得了诺贝尔奖,40多年来,HBsAg仍是诊断HBV感染最基本的血清学标志物[1]。虽然血清HBsAg定量检测已有20余年的历史,但并未得到人们的重视,仍仅作为血液筛查或HBV感染的诊断[2]。近年来,随着血清HBsAg定量
HBV envelope protein is the outer membrane of HBV particles is part of the virus is determined to be adsorbed to susceptible cell receptor components encoded genes encoding the envelope protein pre-S1, pre-S2 and S three coding regions were encoded before S1 Protein, Pre-S2 Protein and HBsAg. HBsAg is a transmembrane glycoprotein that is released in large quantities into the serum of patients during HBV infection. Since 1965 Blumberg found that HBsAg is used to diagnose HBV infection and won the Nobel Prize, HBsAg remains the most basic serological marker for the diagnosis of HBV infection for more than 40 years. Although the quantitative detection of serum HBsAg has been more than 20 years old, it has not received much attention and is only used for the diagnosis of blood screening or HBV infection [2]. In recent years, with the serum HBsAg quantitative