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细胞遗传学研究表明,染色体易位能激活细胞癌基因,特别是Burkitt淋巴肉瘤的MYC癌基因和慢性粒细胞白血病的ABL/bcr融合基因。易位也能使基因序列扩增,而癌基因扩增又被认为在肿瘤病程中起一定作用。在唾液腺多形性腺瘤、脂肪瘤、粘液样脂肉瘤以及子宫平滑肌瘤的染色体12q13-15区段显现一致性重排,而子宫平滑肌瘤的多数染色体重排为12号和14号染色体相互易位所致,即t(12;14)(q14-15;q23-24)。这就有理由认为12q13-15区段内的肿瘤相关基因很可能是一种癌基因,在这一区段发生重排后的基因产生非特
Cytogenetics studies show that chromosomal translocations activate the oncogenes, in particular the MYC oncogene of Burkitt’s lymphosarcoma and the ABL / bcr fusion gene on chronic myeloid leukemia. Translocations also amplify gene sequences, which are thought to play a role in tumor progression. In salivary gland pleomorphic adenoma, lipoma, myxoid liposarcoma, and uterine leiomyoma chromosome 12q13-15 sections showed consistent rearrangement, while the majority of uterine leiomyoma chromosome rearrangements 12 and 14 chromosomes Metabolism caused by that t (12; 14) (q14-15; q23-24). It is reasonable to assume that the tumor-associated gene in the 12q13-15 region is likely to be an oncogene in which rearrangement of genes occurs