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目的 :探讨肺癌患者血清 4项糖类抗原水平的变化及对预后评估的意义。方法 :4项糖类抗原均采用放射免疫分析。结果 :32例不同组织亚型肺癌患者血清 4项糖类抗原水平均显著高于正常对照组及肺良性病变组 (p <0 0 1 ,p <0 0 1 ) ;且腺癌组均显著高于鳞癌及小细胞肺癌组 ,其排序为腺癌 >鳞癌 >小细胞癌。TNM临床分期结果为Ⅰ +Ⅱ期组测定值显著低于Ⅲa期组 (p <0 0 5 ) ;Ⅲa期组测定显著低于Ⅲb +Ⅳ期组 (p <0 0 5 ) ,而Ⅲb +Ⅳ期组更显著高于Ⅰ +Ⅱ期组 (p <0 0 1 )。呈肺癌病程较晚 ,水平越高。结论 :肺癌患者血清 4项糖类抗原测定对诊断及预后的评估有一定临床价值。
Objective: To investigate the changes of serum levels of four carbohydrate antigens in patients with lung cancer and evaluate their prognostic significance. Methods: Four carbohydrate antigens were radioimmunoassay. Results: The serum levels of four carbohydrate antigens in 32 patients with different subtypes of lung cancer were significantly higher than those in normal control group and benign lung group (p <0.01, p <0.01), and were significantly higher in adenocarcinoma group In squamous cell carcinoma and small cell lung cancer group, the order was adenocarcinoma> squamous cell carcinoma> small cell carcinoma. The clinical stage of TNM was significantly lower in group Ⅰ + Ⅱ than in group Ⅲa (p <0.05), that in group Ⅲa was significantly lower than that in group Ⅲb + Ⅳ (p <0.05), while that in group Ⅲb + Ⅳ The stage group was significantly higher than the stage Ⅰ + Ⅱ group (p <0.01). Lung disease was late, the higher the level. Conclusion: There are some clinical values for the diagnosis and prognosis of serum carbohydrate antigen in lung cancer patients.