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目的:分析睡眠呼吸暂停低通气综合征(SAHS)与老年2型糖尿病肾病(DKD)的相关性并探讨可能的影响机制。方法:选取2018年3月至2019年1月在广州市第一人民医院老年内分泌科住院且曾行睡眠呼吸监测的老年2型糖尿病(T2DM)患者84例，根据呼吸睡眠暂停低通气指数(AHI)将患者分为无或轻度SAHS组、中度SAHS组及重度SAHS组，收集患者的一般资料、尿白蛋白/肌酐比值(UACR)、血液生化指标，估算肾小球滤过率(eGFR)，比较三组间参数的差异。并采用多元回归分析影响老年2型糖尿病患者eGFR、lnUACR水平的因素。结果:中度、重度SAHS组最低SpOn 2、eGFR低于无或轻度SAHS组，UACR、同型半胱氨酸(Hcy)、血清淀粉样蛋白A(SAA)、AHI、氧减饱和度指数(ODI)、血肌酐、胱抑素C、超敏C反应蛋白(hsCRP)水平高于无或轻度SAHS组(n P<0.05)；SAHS严重程度与慢性肾脏病(CKD)分期和白蛋白尿水平呈正相关(n r＝0.504，0.382，n P<0.05)；多元线性回归模型提示lnAHI、糖化血红蛋白(HbA1c)及收缩压与eGFR独立相关；lnAHI及收缩压与lnUACR(UACR的自然对数)独立相关；ODI、性别及年龄与eGFR独立相关，ODI及收缩压与lnUACR独立相关。n 结论:SAHS是老年2型糖尿病肾病的独立危险因素，其机制可能与氧化应激及炎症反应有关。“,”Objective:To analyze the association of sleep apnea hypopnea syndrome (SAHS) and diabetic kidney disease (DKD) in elderly type 2 diabetes (T2DM) patients and to explore possible mechanism.Methods:84 elderly hospitalized patients with T2DM and had underwent sleep breathing monitoring in Guangzhou First People's Hospital during March 2018 to January 2019 were collected.Those patients were divided into three groups according to their apnea-hypopnea indices (AHI): no or mild SAHS group, moderate group and severe group. The general clinical data, blood biochemical indexes, urinary albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) were collected and compared among the three groups. Multiple regression analysis was used to analyze the influencing factors of eGFR and lnUACR in elderly patients with type 2 diabetes.Results:The lowest SpOn 2 and eGFR in moderate and severe SAHS group were lower than those in no or mild SAHS group, while the UACR, homocysteine (Hcy), serum amyloid (SAA), AHI, oxygen desaturation index (ODI), serum creatinine, Cystatin C and high sensitivity C-reactive protein (hsCRP) were higher in moderate and severe SAHS group than those in no or mild SAHS group (n P<0.05). The severity of SAHS was positively correlated with the stage of chronic kidney disease (CKD) and albuminuria level (n r=0.504, 0.382, n P<0.05). Multiple linear regression model showed that lnAHI, hemoglobin A1c (HbA1c) and systolic blood pressure (SBP) were independently correlated with eGFR; lnAHI and SBP were independently correlated with lnUACR; ODI, gender and age were independently correlated with EGFR; ODI and SBP were independently correlated with lnUACR.n Conclusions:SAHS is an independent risk factor for renal complications in elderly diabetic patients, and its mechanism may be related to oxidative stress and inflammatory reaction.