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Objective To elucidate the expression and clinical significance or C-erbB-2 in the tissue of lung cancer. Method Immunohistochemistry method was used to detect the protein expression or C-erbB-2 in lung can- cer tissue. Results The positive expression rate of C-erbB-2 protein in 38 cases or lung cancer was 53. 3% (21/38), which was higher than those in lung benign control group (P<0.001). The significant correlation were found between the protein level and tumor stage(r= +0. 64,P<0.02). The order was stage IV>stage Ⅲ>stage,Ⅱ>stage I. There was no correlation among protein expression or C-erhB-2 in various histological types of lung cancer (P>0.05 for all). Conclusion The positive expression rates of C-erbB-2 were significantly higher in lung cancer group than those in benign control group. There is significant correlation between C-erbB-2 expression and lung cancer stage. There is no correlation among protein expression of C-erbB-2 and histological types or lung cancer.
Objective To elucidate the expression and clinical significance or C-erbB-2 in the tissue of lung cancer. Method Immunohistochemistry method was used to detect the protein expression or C-erbB-2 in lung can- cer tissue. Results The positive expression rate of C-erbB-2 protein in 38 cases or lung cancer was 53. 3% (21/38), which was higher than those in lung benign control group (P<0.001). The significant correlation was found between between the protein level and tumor. Stage(r= +0. 64,P<0.02). The order was stage IV>stage III>stage,II>stage I. There was no correlation among protein expression or C-erhB-2 in various histological types of lung cancer (P>0.05 for all). Conclusion The positive expression rates of C-erbB-2 were significantly higher in lung cancer group than those in benign control groups. There is significant correlation between C-erbB-2 expression and lung cancer stage. There Is no correlation among protein expression of C-erbB-2 and histological types or lung cancer.