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目的：探讨组化染色及免疫组化在宫颈腺癌与宫内膜腺癌诊断价值及临床意义。方法：采用组化染色及免疫组化Ｓ－Ｐ方法对宫颈腺癌及宫内膜腺癌的粘蛋白含量、分布及免疫组化阳性物的表达进行观察。结果：宫颈腺癌以含丰富的唾液酸粘蛋白为主，而子宫内膜腺癌以硫酸粘蛋白为主。波形蛋白（ｖｉｍｅｎｔｉｎ）在宫内膜腺癌阳性表达率６８．９％，而宫颈腺癌大多呈阴性表达，雌激素受体（ＥＲ）表达在宫内膜腺癌达６０．９％，而宫颈腺癌仅１９．６％，两者均差异有显著性（Ｐ＜０．０５）。而抑癌基因ｐ５３和癌基因ｃ－ｅｒｂＢ－２阳性率与癌肿的分级和预后有关。结果：粘蛋白组化染色及ｖｉｍｅｎｔｉｎ可帮助鉴别诊断宫颈腺癌及宫内膜腺癌，而ＥＲ、ｐ５３、ｃ－ｅｒｂＢ－２对病人的预后有一定意义
Objective: To investigate the diagnostic value and clinical significance of histochemical staining and immunohistochemistry in cervical adenocarcinoma and endometrial adenocarcinoma. Methods: Immunohistochemistry and immunohistochemistry S-P method of cervical adenocarcinoma and endometrial adenocarcinoma mucin content, distribution and expression of immunohistochemical positive were observed. Results: Cervical adenocarcinoma is rich in sialic mucin, while endometrial adenocarcinoma is mainly mucin. The positive expression rate of vimentin in endometrial adenocarcinoma was 68.9%, while most of the cervical adenocarcinomas were negative. The expression of estrogen receptor (ER) in endometrial adenocarcinoma reached 60.9% Adenocarcinoma only 19.6%, both differences were significant (P <0.05). The tumor suppressor gene p53 and oncogene c-erbB-2 positive rate and the classification of cancer and prognosis. Results: Mucin histochemical staining and vimentin could be used to differentiate cervical adenocarcinoma from endometrial adenocarcinoma. ER, p53 and c-erbB-2 have some significance for the prognosis of patients