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目的评价过敏性紫癜(HSP)患儿尿中结缔组织生长因子(CTGF)水平变化的临床意义。方法将山东大学附属省立医院2006年7月至2007年3月收治的85例HSP患儿按照尿白蛋白排泄率(UAER)分成正常白蛋白尿组(Ⅰ组,25例)、微量白蛋白尿组(Ⅱ组,31例)和大量白蛋白尿组(Ⅲ组,29例),检测各组尿液CTGF,并与27名健康儿童进行比较。结果各组HSP患儿尿液CTGF质量浓度[Ⅰ组:(1.332±0.704)μg/L;Ⅱ组:(8.245±3.790)μg/L;Ⅲ组:(11.013±5.674)μg/L]显著高于对照组[(0.547±0.329)μg/L,P<0.05],HSP患儿各组间比较差异也有显著意义(P<0.05),且随着尿白蛋白排泄率的增加呈递增趋势;尿CTGF与Ⅳ型胶原、UAER呈显著正相关(r=0.495,P<0.01;r=0.542,P<0.01)。结论CTGF在紫癜性肾炎(HSPN)的发生发展中起一定的作用,尿CTGF质量浓度可作为诊断HSPN的敏感指标之一,并有助于判断病情的进展。
Objective To evaluate the clinical significance of the changes of urinary connective tissue growth factor (CTGF) in children with Henoch-Schonlein purpura (HSP). Methods Eighty - five cases of HSP patients admitted to Provincial Hospital of Shandong University from July 2006 to March 2007 were divided into normal albuminuria group (group Ⅰ, 25 cases), urinary albumin excretion rate (UAER), microalbumin Urine group (group Ⅱ, 31 cases) and a large number of albuminuria group (group Ⅲ, 29 cases). Urinary CTGF in each group was detected and compared with 27 healthy children. Results The urinary CTGF concentration of HSP in each group was significantly higher than that of the control group (group Ⅰ: 1.332 ± 0.704 μg / L; group Ⅱ: 8.245 ± 3.790 μg / L; group Ⅲ: 11.013 ± 5.674 μg / L) In the control group [(0.547 ± 0.329) μg / L, P <0.05], there was significant difference between the groups of HSP (P <0.05), and increased with the increase of urinary albumin excretion rate; urine CTGF was positively correlated with type Ⅳ collagen and UAER (r = 0.495, P <0.01; r = 0.542, P <0.01). Conclusion CTGF plays a role in the development of HSPN. Urinary CTGF concentration can be used as one of the sensitive indexes to diagnose HSPN, and help to judge the progress of the disease.