论文部分内容阅读
用大鼠建立甲状腺机能低下（甲低）和甲状腺机能亢进（甲亢）的动物模型。以ＨＰＬＣ法测定地西泮血药浓度，研究甲低和甲亢对地西泮药代动力学的影响。结果表明，甲低组大鼠地西泮血药浓度显著高于对照组（Ｐ＜００５），Ｃｍａｘ升高，ＡＵＣ增大，吸收Ｔ１／２延长，Ｖｄ减小，消除减慢。轻度甲亢组地西泮血药浓度、Ｃｍａｘ及ＡＵＣ与对照组相比无差异，但随着甲亢程度加重，上述指标逐渐增高。轻、中度甲亢组地西泮吸收基本不变，Ｖｄ减小，消除加快；重度甲亢组吸收明显加快，Ｖｄ减小，消除减慢。提示不同甲状腺机能状态对地西泮药代动力学的影响不同
Animal models of hypothyroidism (hypothyroidism) and hyperthyroidism (hyperthyroidism) were established in rats. The plasma concentration of diazepam was determined by HPLC, and the effect of hypothyroidism and hyperthyroidism on the pharmacokinetics of diazepam was studied. The results showed that the plasma concentration of diazepam in hypothyroidism group was significantly higher than that in the control group (P <005). Cmax increased, AUC increased, absorption of T1 / 2 prolonged, Vd decreased and disappearance slowed down. Mild hyperthyroidism group diazepam plasma concentration, Cmax and AUC compared with the control group no difference, but with the degree of hyperthyroidism increased, the above indicators increased. In mild and moderate hyperthyroidism group, the absorption of diazepam remained unchanged, Vd decreased and disappeared; the absorption of severe hyperthyroidism group was accelerated obviously, Vd was reduced and disappeared. Suggesting that different thyroid functional status on the pharmacokinetics of diazepam different