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目的统计分析胃肠外疾病患者幽门螺杆菌的感染率,对其与胃肠外疾病发病的相关性进行探讨,为预防和临床治疗提供指导。方法调查2010年2月-2012年8月1 534例胃肠外疾病患者、1 938例单纯胃肠道疾病患者及748例胃肠外疾病合并胃肠道疾病患者,选取同期593名健康人群作为对照,通过14 C-尿素呼气试验进行检测,采用SPSS11.0软件对所有患者资料进行统计分析。结果胃肠外疾病患者中有1 065例患者14 C-尿素呼气试验阳性,阳性率为69.4%;进行检测的593名健康人中,有302人的检验结果阳性,阳性率为50.9%;糖尿病、血小板减少性紫癜(ITP)、结缔组织病、过敏性紫癜患者感染幽门螺杆菌的阳性率分别为75.2%、76.4%、66.7%、79.2%,均显著高于健康人群(P<0.05);单纯胃肠道疾病的患者中有1 309例患者结果阳性,阳性率为67.5%;糖尿病、ITP合并胃肠道疾病患者的幽门螺杆菌感染阳性率要显著高于单纯胃肠道疾病患者,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染在消化道外疾病发生发展中可能起到重要的作用,但其是否相关还需要进一步的研究。
Objective To analyze the infection rate of Helicobacter pylori in patients with parenteral diseases and to explore its correlation with the incidence of parenteral diseases and provide guidance for prevention and clinical treatment. Methods A total of 1 534 patients with parenteral diseases, 1 938 patients with simple gastrointestinal diseases and 748 patients with parenteral diseases complicated with gastrointestinal diseases were enrolled in the study from February 2010 to August 2012. 593 healthy people in the same period were selected as Control, by 14 C-urea breath test to detect the use of SPSS11.0 software for statistical analysis of all patient data. Results Among the 533 healthy volunteers, the positive rate of 14 C-urea breath test was positive in 1065 patients with parenteral diseases, and the positive rate was 50.9%. The positive rates of Helicobacter pylori infection in patients with diabetes, thrombocytopenic purpura (ITP), connective tissue disease and allergic purpura were 75.2%, 76.4%, 66.7% and 79.2%, respectively, which were significantly higher than those in healthy people (P <0.05) ; Of the 309 patients with simple gastrointestinal diseases, the positive result was 67.5%. The positive rate of Helicobacter pylori infection in patients with diabetes and ITP complicated with gastrointestinal diseases was significantly higher than that in patients with simple gastrointestinal diseases, The difference was statistically significant (P <0.05). Conclusion Helicobacter pylori infection may play an important role in the development of diseases outside the digestive tract. However, whether it is related or not needs further study.