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[目的]研究三唑磷对大鼠神经行为的影响作用。[方法]40只体重60～80 g的SD大鼠,雌雄各半,随机分成4组,将受试物掺入饲料中给予染毒,共设对照、低、中、高4组,剂量分别为0、25、100、400 mg/kg。给予受试物16周后进行Morris水迷宫试验测试神经行为功能。[结果]在定向导航试验中,在不同训练期中、高剂量组雄性大鼠的潜伏期有不同程度的延长,且与对照组相比差异有统计学意义(P<0.05),雌性大鼠各训练期的逃避潜伏期与对照组相比差异无统计学意义;在空间探索试验中,低、中、高剂量组雌性大鼠的平均运动速度与对照组大鼠相比差异均有统计学意义(P<0.05);中、高剂量组雌性大鼠在目标象限的活动时间与对照组相比有显著减少(P<0.05);雄性大鼠高剂量组站台周围活动时间与对照组有显著减少(P<0.05),雌性大鼠的中、高剂量组站台周围活动时间与对照组相比有显著减少(P<0.05)。[结论]三唑磷可对大鼠的神经行为产生一定的影响。
[Objective] To study the effect of triazophos on neurobehavioral activity in rats. [Method] Forty SD rats weighing 60-80 g were divided into 4 groups at random. The rats were randomly divided into 4 groups. The rats were randomly divided into four groups: control, low, middle and high dose groups 0, 25, 100, 400 mg / kg. After 16 weeks of administration, Morris water maze test was performed to test neurobehavioral function. [Results] In the course of directional navigation test, the latency of male rats in high dose group was prolonged to different extents in different training periods, and the difference was statistically significant compared with control group (P <0.05). The training of female rats There was no significant difference in the escape latency between the two groups compared with the control group. In the spatial exploration test, the average speed of the female rats in the low, medium and high dose groups was significantly different from that in the control group (P <0.05). The activity time of the female rats in the medium and high dose groups in the target quadrant decreased significantly compared with that in the control group (P <0.05). The activity time of the high dose group in the male rats decreased significantly compared with that in the control group <0.05). The activity time around the platform of the middle-dose and high-dose groups of female rats was significantly decreased compared with that of the control group (P <0.05). [Conclusion] Triazophos can exert a certain influence on the neurological behavior of rats.