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在坦桑尼亚终年流行疟疾的Muheza地区,选择312名早中期孕妇,随机分成三组(氯喹组,氯胍组,氯喹+氯胍组),测定预防药对孕妇免疫力的影响。测试前一周受检者均服法西达片,然后在监督下接受预防药,即氯喹300mg(基质)每周一次,氯胍200mg每天一次,氯喹+氯胍组合用前量。服药前采静脉血2ml,服药后每隔8周同样采血2ml,用ELISA法以R32tet32(重组的恶性疟原虫环子孢子蛋白)检测血清中抗子孢子抗体水平。
In Muheza, a year-long endemic area of malaria in Tanzania, 312 early-to-middle-term pregnant women were selected and randomized to three groups (chloroquine, proguanil, chloroquine + proguanil) to determine the effect of prophylaxis on pregnant women’s immunity. A week before the test subjects were fasted with faxidac tablets, and then under the supervision of receiving prophylaxis, that chloroquine 300mg (matrix) once a week, 200mg of proguanil once daily, chloroquine + proguanil combination pre-dose. Blood samples taken before taking 2ml venous blood 2ml after taking the medication every 8 weeks, using ELISA to R32tet32 (recombinant Plasmodium falciparum circumsporozoite protein) serum anti-sporozoite antibody levels.