论文部分内容阅读
目的探讨Hedgehog信号通路中Smo及Gli1蛋白在乳腺癌组织中的表达及临床意义。方法采用免疫组化法分别检测本院2009.02-2013.02期间79例乳腺癌、68例癌旁正常组织及42例乳腺纤维腺瘤组织中Smo和Gli1蛋白的表达,并分析两者的表达水平与乳腺癌临床病理特征的关系。结果 Smo和Gli1蛋白在乳腺癌组织中的阳性率分别为(73.4%、77.2%),与癌旁正常组织(21.4%、19.0%)及乳腺纤维腺瘤组织(20.6%、23.5%)比较,差异有统计学意义(P=0.023,P=0.045)。Smo和Gli1蛋白表达与患者临床病理分期(P=0.041,P=0.034)及是否腋窝淋巴结转移(P=0.003,P=0.006)有关,而与年龄(P=0.109,P=0.107)及病理类型无关(P=0.078,P=0.083);相关分析显示Smo和Gli1蛋白在乳腺癌组织中的表达呈正相关(r=0.527,P=0.038)。结论Hedgehog信号通路中Smo与Gli1蛋白的异常高表达可能在乳腺癌的发生和发展中起重要作用。
Objective To investigate the expression and clinical significance of Smo and Gli1 in Hedgehog signaling pathway in breast cancer. Methods The expressions of Smo and Gli1 protein in 79 cases of breast cancer, 68 cases of adjacent normal tissue and 42 cases of breast fibroadenoma were detected by immunohistochemistry in our hospital from February 2009 to February 2013. The expressions of Smo and Gli1 protein in breast cancer tissues were analyzed. Relationship between clinicopathological characteristics and cancer. Results The positive rates of Smo and Gli1 in breast cancer tissues were 73.4% and 77.2%, respectively, which were significantly higher than those in normal breast tissues (21.4%, 19.0%) and breast fibroadenomas (20.6%, 23.5% The difference was statistically significant (P = 0.023, P = 0.045). The expressions of Smo and Gli1 were correlated with the clinicopathological stage (P = 0.041, P = 0.034) and axillary lymph node metastasis (P = 0.003, P = 0.006) (P = 0.078, P = 0.083). Correlation analysis showed that there was a positive correlation between Smo and Gli1 expression in breast cancer (r = 0.527, P = 0.038). Conclusion The abnormally high expression of Smo and Gli1 in Hedgehog signaling pathway may play an important role in the occurrence and development of breast cancer.