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目的：探讨神经导航系统辅助下手术治疗急性脑梗死患者的疗效与机制。方法：2012年7月到2015年2月选择在医院诊治的急性脑梗死患者78例，根据随机数字表法分为观察组与对照组各39例，对照组采用传统手术治疗，观察组给予神经导航系统辅助下手术治疗，观察两组预后情况。结果：术后观察组与对照组的有效率分别为94.9%和82.1%，观察组的有效率明显高于对照组（P<0.05）。术后观察组与对照组NIHSS评分分别为（6.34±1.34）分和（9.19±1.84）分，都明显低于术前的（14.24±1.56）分和（14.29±1.87）分（P<0.05），观察组术后NIHSS评分也明显低于对照组（P<0.05）。观察组术后7d的再出血、颅内感染、迟发脑积水等并发症发生情况都明显少于对照组（P<0.05）。术后观察组与对照组血清基质金属蛋白酶-9(MMP-9)含量分别为（82.34±12.84）ng/ml和（182.34±11.45）ng/ml，都明显低于术前的（534.24±16.11）ng/ml和（531.29±21.24）ng/ml（P<0.05），同时组间对比差异有统计学意义（P<0.05）。结论：神经导航系统辅助下手术治疗急性脑梗死能促进神经功能障碍的缓解，降低并发症的发生，从而提高治疗疗效，其作用的发挥可能与有效促进血清MMP-9含量降低有关。“,”Objective: To discuss about the curative effect and mechanism of surgical treatment of acute cerebral infarction patient with the assistance of neuronavigation system. Methods: There were 78 acute cerebral infarction patients who selected to be treated in our hospital from July 2012 to February 2015. Those patients were divided into observation group and control group in accordance with random number table, 39 cases for each group. The control group adopted the traditional surgical treatment while the observation group was given surgical treatment with the assistance of Neuronavigation system. The prognosis conditions of the two groups were observed. Results: The effective rate after surgery of the observation group and the control group separately was 94.9% and 82.1%. The effective rate of the observation was significantly higher than that of the control group (P<0.05). NIHSS score of post-operation observation group and control group separately was (6.34±1.34) and (9.19±1.84), both of which were significantly lower than (14.24±1.56) and (14.29±1.87) before operation (P<0.05). Besides, the postoperative NIHSS score of the observation group was also significantly lower than that of control group (P<0.05). The occurrence conditions of re-hemorrhage, intracranial infection, tardive hydrocephalus and other complications 7 days after operation of the observation group were significantly less than that of the control group(P<0.05).The serum matrix metalloproteinase -9(MMP-9)content after operation of observation group and control group separately was (82.34±12.84)ng/ml and (182.34±11.45)ng/ml, both of which were significantly lower than (534.24±16.11)ng/ml and (531.29±21.24)ng/ml before operation (P<0.05). The contrast difference between the groups has the statistical significance (P<0.05). Conclusion: The surgical treatment of acute cerebral infarction with the assistance of neuronavigation system can accelerate the relieving of dysneuria and lower the occurrence of complications and thus can improve the curative effect. The function may be caused by the effective acceleration of lowering of serum MMP-9 content.