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虽然对石油烃溶剂的环境和职业性危害已有所了解,但对这种工业溶剂毒作用的可能方式仍不很清楚。因而用大白鼠进行了血浆、肝和肾脏中碱性磷酸酶改变的研究,以作为探测石油溶剂初步毒性生化参数的一个部分。14组大鼠,每组10只,以苯、CCl_4、汽油、石油醚或IOMex~*作腹腔内注射,3ml/kg/天;其中两组的剂量为2ml/kg。实验结束后杀死动物,将内脏制成匀浆,进行测定。实验结果:四个烃类组动物的肝脏碱性磷酸酶活性显著增高(p<0.01),脑内该酶无明
Although the environmental and occupational hazards of petroleum hydrocarbon solvents are known, the possible ways of poisoning this industrial solvent remain unclear. Therefore, studies on the changes of alkaline phosphatase in plasma, liver and kidney were carried out in rats as a part of the preliminary toxicological biochemical parameters for the detection of petroleum solvents. The rats in group 14 were intraperitoneally injected with 3 ml / kg / day of benzene, CCl 4, gasoline, petroleum ether or IOMex ~ *. The dosage of the two groups was 2 ml / kg. After the experiment, the animals were killed and the viscera was homogenized for determination. The results showed that the hepatic alkaline phosphatase activities of four hydrocarbon groups were significantly increased (p <0.01)