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目的:探讨不同剂量奥扎格雷治疗急性脑梗死的临床药物剂量效应关系。方法:275例急性脑梗死病人分成3组。在常规治疗(吡拉西坦,维生素E,胞磷胆碱,血栓通等)基础上,治疗Ⅰ组:给奥扎格雷80mg,静脉输入,10天;治疗Ⅱ组:给奥扎格雷40mg,静脉输入,10天;对照组:仅用常规治疗。结果:治疗Ⅰ组总有效率97%,治疗Ⅱ组总有效率96%,对照组总有效率82%,3组间疗效比较经Ridit分析,治疗Ⅰ组、治疗Ⅱ组与对照组临床疗效比较均有非常明显差异(P<0.01),而治疗Ⅰ组与治疗Ⅱ组比较,差异不显著(P>0.05),治疗组除少数病人出现皮疹、恶心外,未出现严重不良反应。结论:不同剂量奥扎格雷治疗急性脑梗死都有肯定疗效。
Objective: To investigate the dose-effect relationship of different doses of ozagrel in the treatment of acute cerebral infarction. Methods: 275 patients with acute cerebral infarction were divided into 3 groups. On the basis of routine treatment (piracetam, vitamin E, citicoline, thrombus, etc.), the treatment group Ⅰ: Ozagrel 80mg, intravenous infusion for 10 days; treatment group Ⅱ: Ozagrel 40mg, Intravenous infusion, 10 days; control group: conventional therapy only. Results: The total effective rate was 97% in group Ⅰ, 96% in group Ⅱ and 82% in control group. The curative effect of group Ⅰ was compared with that of group Ⅰ, group Ⅱ and group Ⅱ (P <0.01). However, there was no significant difference between treatment group Ⅰ and treatment group Ⅱ (P> 0.05). In the treatment group, there were no serious adverse reactions except rash and nausea in a few patients. Conclusion: Ozagrel in different doses has certain curative effect on acute cerebral infarction.