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目的分析细菌感染在COPD患者病情进展中的变化特点。方法选取我院2013年1-6月60例COPD患者,按病情程度不同分组,分别进行痰细菌培养,对比各组患者间临床资料差异性。结果 60例患者细菌痰培养阳性25例,其中COPD普通组阳性3例(12.00%),AECOPD组阳性22例(62.86%),AECOPD组细菌感染率明显高于普通组(P=8.17 E-05);不同分型的AECOPD中,1型阳性率最高,且与2、3型相比,差异存在统计学意义(P<0.05);2组患者共鉴定出致病菌33株(有8例检出2株致病菌),其中COPD普通组检出3株,AECOPD组检出30株,AECOPD细菌数量及种类明显多于普通组。结论细菌感染愈严重COPD患者病情愈严重,细菌感染使COPD患者病情加重,加快了病程发展。
Objective To analyze the changing characteristics of bacterial infection in the progression of COPD patients. Methods Sixty COPD patients in our hospital from January to June, 2013 were selected and divided into groups according to the severity of the disease. Bacterial sputum culture was performed respectively. The differences of clinical data among the groups were compared. Results Among the 60 patients, 25 cases were positive for bacterial sputum culture, among which, 3 cases (12.00%) were positive in COPD group and 22 cases (62.86%) in AECOPD group. The bacterial infection rate in AECOPD group was significantly higher than that in common group (P = 8.17 E-05 ). The positive rate of type 1 was the highest in AECOPD with different types, and there was a significant difference compared with type 2 and 3 (P <0.05) .33 strains of pathogens were identified in both groups (8 cases Two strains of pathogens were detected. Among them, 3 strains were detected in COPD normal group and 30 strains were detected in AECOPD group. The numbers and types of AECOPD bacteria were significantly more than those in normal group. Conclusion The more severe bacterial infections in COPD patients the more serious the disease, bacterial infection in patients with COPD exacerbations, to speed up the course of development.