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观察了枢复宁对大剂量马法兰（ＨＭ）及阿糖胞苷（ＨＡ）所致恶心呕吐的预防作用，并与胃复安的止吐效果进行了对照比较。根据ＨＡ所致恶心呕吐的特点，对选择性用药进行了尝试。枢复宁对ＨＡ所致恶心和呕吐的预防率分别为５４％和７８％，且程度明显减轻（Ｐ＜０．０１），对ＨＭ所致重度恶心的预防率达１００％，对呕吐的预防率达７８％，呕吐次数明显减少（Ｐ＜０．０１），提示这种５—羟色胺受体拮抗剂能够有效地控制ＨＭ和ＨＡ引起的恶心呕吐。尚未观察到枢复宁明显的毒副作用。
The preventive effect of Shufuning on nausea and vomiting caused by high dose melphalan (HM) and cytarabine (HA) was observed and compared with antiemetic effect of metoclopramide. According to the characteristics of nausea and vomiting caused by HA, selective medication was tried. The rate of prevention and treatment of nausea and vomiting caused by HA was 54% and 78% respectively (P <0.01), and the prevention rate of severe nausea caused by HM was 100% The rate of vomiting was significantly reduced (78%) (P <0.01), suggesting that this serotonin receptor antagonist can effectively control the HM and HA-induced nausea and vomiting. No obvious side effects of the pivotal Ning have been observed.