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目的:通过内镜下观察口服腐蚀剂后上消化道黏膜损伤情况,探讨白细胞(WBC)、C-反应蛋白(CRP)与损伤程度之间关系,为病情判断提供依据,同时为进行早期干预治疗提供研究基础。方法:回顾性分析150例口服腐蚀剂致上消化道损伤患者,评估内镜下上消化道损伤程度,分析性别、年龄、WBC、CRP与损伤程度之间的相关性,同时将相关性因素与损伤分级进行两两比较。结果:根据Zargar损伤分级标准,将上消化道损伤分级,可分为Grade0、Ⅰ、Ⅱa、Ⅱb、Ⅲa、Ⅲb级,将患者一般情况、WBC、CRP进行Spearman秩相关分析,得出WBC、CRP与损伤相关,差异有统计学意义(P<0.05);将WBC、CRP与食管、胃分级之间进行K-Wallis秩和检验比较,发现WBC、CRP值越高,消化道损伤程度越严重。结论:WBC、CRP为消化道损伤严重程度的相关因素,同时WBC、CRP值越高,消化道损伤程度越严重。
OBJECTIVE: To investigate the relationship between WBC and C-reactive protein (CRP) and the extent of damage after oral administration of oral etchant by observing the damage of upper gastrointestinal mucosa by oral gavage, and to provide the basis for the judgment of the disease and provide the basis for early intervention treatment research Foundation. Methods: A retrospective analysis of 150 cases of oral corrosive agents induced upper gastrointestinal tract injury in patients with endoscopy to assess the degree of upper gastrointestinal tract injury, analysis of gender, age, WBC, CRP and the degree of injury, while the correlation between the factors and damage Grading for a pair of comparisons. Results: According to the Zargar injury grading standards, the upper gastrointestinal lesions were graded and classified into Grade0, Ⅰ, Ⅱa, Ⅱb, Ⅲa and Ⅲb. Spearman rank correlation analysis was performed on the general condition, WBC and CRP. (P <0.05). The K-Wallis rank sum test between WBC, CRP and esophageal and gastric grading showed that the higher the WBC and CRP values, the more severe the damage of the digestive tract. Conclusion: WBC and CRP are the related factors of the severity of digestive tract injury. The higher the WBC and CRP values are, the more serious the damage of digestive tract is.