论文部分内容阅读
探讨黄芪对脑系膜上动脉闭塞（SMAO）性休克时肺损伤的防治作用及其机制。方法复制家兔SMAO性休克模型，观察黄芪对入、出肺血及肺组织超氧化物歧化酶（SOD）、黄嘌呤氧化酶（XO）、丙二醛（MDA）及肺表面活性物质（PS）含量的影响，观察小肠及肺的病理变化。结果静脉给予黄芪注射液可使XO及MDA含量降低，且可防止SOD和PS减少，避免了休克及肺损伤的进行性加剧。结论SMAO休克过程中伴有肺损伤。黄芪通过抗脂质过氧化能减轻或在一定程度上防止休克肺的发生和发展。
To explore the preventive and therapeutic effects of Radix Astragali on lung injury in patients with superior brain arterial occlusion (SMAO) shock. Methods A rabbit model ofSMAO shock was replicated and the superoxide dismutase (SOD), xanthine oxidase (XO), malondialdehyde (MDA), and pulmonary surfactant (PS) in the lungs were observed. ) The effect of the content was observed on the pathological changes of the small intestine and lung. RESULTS: Intravenous administration of Astragalus membranaceus could reduce the content of XO and MDA, prevent the decrease of SOD and PS, and avoid the progressive worsening of shock and lung injury. Conclusion There is lung injury during the shock of SMAO. Astragalus can reduce or to some extent prevent the occurrence and development of shock lung through anti-lipid peroxidation.