Phenotypic research on senile osteoporosis caused by SIRT6 deficiency

• 作 者: De-Mao Zhang Di-Xin Cui Ruo-Sh
• 机 构: StateKeyLaboratoryofOralDiseases
• 出 处: 国际口腔科学杂志：英文版
• 发表日期: 2016年2期
• 关键词: 骨质疏松症 基因缺陷 老年性 表型 骨髓间充质干细胞 骨髓基质细胞 破骨细胞 成骨细胞 ageing osteoclastogenesis osteogen
• 基金项目: This study was supported by NSFC grants 81371136 and JCPT2011-9 （Xue-Dong Zhou）, and NSFC grants 81470711 and 81200760 （Li-Wei Zheng）. We thank Ling Ye （Professor, Sate Key Laboratory of Oral Diseases

Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing,which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock ou