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目的研究胰岛素抵抗及其继发的糖脂代谢紊乱与心脑大血管病变的关系。方法对38例血糖异常合并大血管病变病人、37例单纯血糖异常病人、39例单纯大血管病变无血糖异常病人及39例正常对照者的BM I、血压、空腹血糖、血脂、HOMA IR等指标进行对照。结果血糖异常组无论有无大血管病变(1、2)其HOMA IR、BM I、TG均大于对照组(4)及单纯大血管病变组(3),血糖异常合并大血管病变组(1)HOMA IR、BM I、TG最高,HOMA IR与BM I、TG有明显相关性,而与血压、HDL、LDL无明显相关,后三者在大血管病变组(1、3)较单纯血糖异常(2)和正常对照组(4)有显著差别。结论我们观察胰岛素抵抗可以导致血糖、血脂代谢紊乱,以及血压的异常,其中高血脂、高血压是大血管病变的重要危险因素。本组结论高血糖与大血管病变无直接影响。
Objective To study the relationship between insulin resistance and its secondary dyslipidemia and cardiovascular and cerebrovascular diseases. Methods BM I, blood pressure, fasting blood glucose, blood lipids, HOMA IR and other indicators of 38 patients with abnormal blood glucose and macrovascular disease, 37 patients with simple blood glucose abnormalities, 39 patients with pure macrovascular complications without blood glucose abnormalities and 39 normal controls were measured. For comparison. Results The HOMA IR, BM I and TG of the abnormal blood glucose group were significantly higher than those of the control group (4) and the simple macroangiopathy group (3), the abnormal blood glucose group and the macrovascular disease group (1), with or without macroangiopathy HOMA IR, BM I and TG were the highest, HOMA IR was significantly correlated with BM I and TG, but not with blood pressure, HDL and LDL. The latter three were significantly higher than those with simple blood glucose (1,3) 2) and normal control group (4) there are significant differences. Conclusion We observed that insulin resistance may lead to abnormal blood glucose, dyslipidemia and abnormal blood pressure. Hyperlipidemia and hypertension are important risk factors for macrovascular diseases. The conclusion of this group no direct impact on hyperglycemia and macrovascular disease.