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目的对多药耐药基因1(MDR1)外显子26(rs1045642)与急性淋巴细胞白血病(ALL)的关系进行系统评价。方法检索中英文数据库2016年8月31日之前发表的关于MDR1基因多态性和ALL关系的文献资料,应用RevMan5.3软件进行系统评价。采用随机效应模型或固定效应模型计算效应指标:OR值和95%CI。结果在纯合子模型、显性模型、超显性模型、隐性模型和等位基因模型中,P<0.05,差异有统计学意义。按种族进行亚组分析,在黄种人中:纯合子模型Z=2.66(P=0.008);超显性模型Z=3.86(P=0.0001);隐性模型Z=2.43(P=0.01);等位基因模型T vs C,Z=2.28(P=0.02),差异均有统计学意义。结论黄种人MDR1基因外显子26(rs1045642)的多态性与ALL易感性有关。基因型TT和等位基因T可能是ALL的易感因素。
Objective To systematically evaluate the relationship between multidrug resistance gene 1 (MDR1) exon 26 (rs1045642) and acute lymphoblastic leukemia (ALL). Methods The Chinese and English databases were searched before and after August 31, 2016 to review the literature about MDR1 gene polymorphism and ALL. The data were analyzed by using RevMan5.3 software. Efficacy indicators were calculated using random effects model or fixed effects model: OR value and 95% CI. Results In homozygous model, dominant model, super-dominant model, recessive model and allelic model, P <0.05, the difference was statistically significant. Subgroup analyzes were conducted by race: in homozygous Z = 2.66 (P = 0.008); Z = 3.86 (P = 0.0001); recessive model Z = 2.43 (P = 0.01); There was significant difference between the two groups in T vs C, Z = 2.28 (P = 0.02). Conclusion The polymorphism of exon 26 (rs1045642) of MDR1 gene is associated with susceptibility to ALL. Genotype TT and allele T may be susceptible to ALL.