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目的:观察应用免疫荧光法检测D-二聚体的结果,并探讨其临床应用价值。方法:纳入紫金县人民医院2014年9月至2015年8月收治的192例患者和同期45例健康体检者,将192例患者设为观察组,将45例健康体检者设为对照组,应用免疫荧光法检测两组对象的D-二聚体浓度,并根据192例患者所患疾病的不同,将观察组分成多个亚组(亚组1~7),对比各个亚组中患者和对照组健康体检者的D-二聚体检测结果。结果:观察组中各亚组患者的D-二聚体浓度均较对照组高,组间比较,差异具有统计学意义(P<0.05)。观察组中各亚组患者的D-二聚体阳性检出率均超过30%。结论:采用免疫荧光法检测D-二聚体浓度,具有简单、快速、灵敏、准确性高的应用优势,机体处于疾病状态时会对血浆中D-二聚体的浓度产生影响,尤其是能够导致血液出现高凝状态及纤溶亢进的疾病。
Objective: To observe the application of immunofluorescence assay D-dimer results and explore its clinical value. Methods: A total of 192 patients admitted to Zijin County People’s Hospital from September 2014 to August 2015 and 45 healthy volunteers were enrolled in this study. 192 patients were enrolled in the observation group and 45 healthy volunteers were enrolled as the control group. The concentrations of D-dimer in both groups were measured by immunofluorescence. The observation group was divided into multiple subgroups (subgroups 1 to 7) according to the different diseases of the 192 patients. The patients and controls in each subgroup were compared D-dimer test results for healthy subjects. Results: The concentration of D-dimer in each subgroup in the observation group was higher than that in the control group. The difference between the two groups was statistically significant (P <0.05). The D-dimer-positive rates in all subgroups in the observation group were over 30%. CONCLUSIONS: The detection of D-dimer concentration by immunofluorescence is simple, rapid, sensitive and has the advantage of high accuracy. When the body is in the diseased state, it will affect the concentration of D-dimer in the plasma. In particular, Lead to blood hypercoagulable state and fibrinolytic disease.