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目的:评价乌司他丁(UTI)对严重烧伤患者重要脏器的保护作用。方法:采用Cochrane系统评价方法,计算机检索Cochrane图书馆、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库,并辅以手工检索,收集乌司他丁对严重烧伤患者重要脏器保护作用的随机对照研究,对符合纳入标准的文献进行Meta分析。结果:共纳入21个随机对照研究,与基础治疗组相比,加用乌司他丁组有较大可能降低严重烧伤患者的病死率(P<0.01);乌司他丁有助于降低严重烧伤患者并发症的发生率(P<0.01);对肝功能和肾功能保护方面,乌司他丁组优于基础治疗组(P<0.01)。结论:乌司他丁有助于降低严重烧伤患者的死亡率,有助于降低并发症的发生率和保护肝、肾功能。由于纳入研究质量的局限性,乌司他丁注射液对保护严重烧伤患者重要脏器的有效性和安全性,仍有待设计严格的高质量随机对照临床研究进一步证实。
Objective: To evaluate the protective effect of UTI on vital organs in patients with severe burn. Methods: The Cochrane systematic review method was used to search the Cochrane Library, Chinese Biomedical Literature Database, Chinese Science and Technology Journals Full-text Database, Chinese Journal Full-text Database, and manual retrieval to collect ulinastatin for the protection of vital organs in severely burned patients Role of the randomized controlled study, met the inclusion criteria for meta-analysis of the literature. Results: A total of 21 RCTs were included. Compared with the basic treatment group, the ulinastatin group was more likely to reduce the mortality of patients with severe burns (P <0.01); ulinastatin The incidence of complications in burn patients was significantly higher than that in the basic treatment group (P <0.01). The liver function and renal function were better in the ulinastatin group than in the basic treatment group (P <0.01). Conclusion: Ulinastatin can reduce the mortality rate of severe burn patients, reduce the incidence of complications and protect liver and renal function. The effectiveness and safety of ulinastatin injection in protecting vital organs in severely burned patients is yet to be confirmed by well-designed high-quality randomized controlled clinical studies due to the limitations of inclusion of research quality.