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目的 观察肾综合征出血热乳鼠脑纯化Ⅰ型灭活疫苗在浙江省肾综合征出血热高发疫区大面积人群接种后的安全性 ,考核血清学和中期流行病学效果。方法 采用IFAT法测特异性IgG抗体 ,用MCPENT法测中和抗体滴度。结果 共接种 10 46 0人 ,全程接种者占 97 30 % ,对照 16 15 9人。全程接种后 2周进行血清学观察 ,荧光抗体阳转率为 10 0 0 0 % (6 7/6 7) ,中和抗体阳转率为 44 44 % ,几何平均滴度分别为 72 12和4 6 2。基础免疫 1年后进行加强免疫 ,加强针免前、免后 2周 ,荧光抗体阳性率分别为 2 8 5 7%、 83 33 % ;中和抗体阳性率分别为 14 80 %、 5 5 5 6 %。基础免疫后 2年、 2 5年和 3年 ,荧光抗体阳性率分别为 75 0 0 %、5 3 13 %和 2 2 5 8% ;中和抗体阳性率分别为 35 0 0 %、 31 2 5 %。疫苗近期 (基础免疫后 1年 )和中期 (基础免疫后 2年和 3年 )流行病学防病效果良好。结论 HFRS疫苗近期和中期流行病学防病效果明显 ,取得了良好的经济和社会效益
Objective To observe the safety of type Ⅰ inactivated purified brain detoxification neonates with hemorrhagic fever with renal syndrome in a large area of population with high incidence of hemorrhagic fever with renal syndrome in Zhejiang Province and evaluate the serological and metaphase epidemiological effects. Methods The specific IgG antibody was detected by IFAT method. The titer of neutralizing antibody was measured by MCPENT method. Results A total of 10 46 0 people were vaccinated, 97 30% of them were vaccinated in the whole process and 16 15 9 were controls. Serological observation was performed 2 weeks after inoculation. The positive rate of fluorescent antibody was 100% (67/67), the positive rate of neutralizing antibody was 44 44%, and the geometric mean titers were 72 12 and 4 respectively 6 2. One year after the basic immunization, the immunization was boosted. The positive rates of fluorescent antibody before and after the needle-free two weeks were 2855% and 8333% respectively. The positive rates of neutralizing antibodies were 14 80% and 556% %. The positive rates of fluorescent antibody were 75 0%, 53 13% and 25 8% respectively at 2, 25 and 3 years after basal immunization. The positive rates of neutralizing antibodies were 35 0 0% and 31 2 5 respectively %. Vaccines Epidemiology Preventative effects are good late (1 year after basal immunization) and in interim (2 years and 3 years after basal immunization). Conclusion The epidemic prevention effect of HFRS vaccine in the short and medium term is obvious, and has achieved good economic and social benefits