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近年来,应用造血细胞移植治疗某些血液疾病已有不少成功的报导。由于组织抗原(HLA)的差异限制了骨髓和外周血造血干细胞移植的广泛应用。胚胎肝脏中含有丰富的、增殖力强的造血干细胞,然而,免疫活性细胞含量却比较低。因此,应用胎肝细胞治疗造血障碍疾病是一个值得探讨的措施。目前,有关机体输入同种胎肝细胞后对免疫功能的影响了解甚少。本文观察了13例慢性再生障碍性贫血病人输注胎肝细胞后对外周血淋巴细胞及其转化的影响。
In recent years, there have been many successful reports of the use of hematopoietic cell transplantation in the treatment of certain blood diseases. Due to differences in tissue antigens (HLA), bone marrow and peripheral blood hematopoietic stem cell transplantation is widely used. Embryonic liver is rich in abundant proliferative hematopoietic stem cells, however, immunocompetent cells are relatively low. Therefore, the application of fetal hepatocytes in the treatment of hematopoietic disorders is a worthy measure. At present, little is known about the effect of the same type of fetal liver cells on immune function. In this paper, 13 chronic aplastic anemia patients were observed after transfusion of fetal liver cells on peripheral blood lymphocytes and their transformation.