论文部分内容阅读
目的观察糜烂性胃炎患者应用依卡倍特钠联合标准三联疗法治疗前后胃黏膜组织学变化。评价糜烂灶组织学愈合质量。方法62例胃镜诊断糜烂性胃炎合并幽门螺杆菌感染的患者取黏膜组织进行病理检查。随机分成观察组和对照组,在使用奥美拉唑、阿莫西林、克拉霉素的基础上,观察组加用依卡倍特钠4周,对照组加用硫糖铝4周,疗程结束后复查胃镜判断糜烂灶愈合质量和14C-尿素呼气试验判断幽门螺杆菌清除率,胃镜下在相当于原取材点处取黏膜组织,观察两组患者治疗后黏膜炎性细胞浸润程度和黏膜形态结构方面的组织学恢复情况。结果两组患者的糜烂灶愈合率、幽门螺杆菌清除率相似(p>0.05),治疗组的胃黏膜组织学愈合质量优于对照组,有极显著性差异(p<0.001)。结论依卡倍特钠有良好的黏膜保护作用,能增强黏膜愈合的组织学质量。
Objective To observe the histological changes of gastric mucosa in patients with erosive gastritis before and after treatment with icarubatis combined with standard triple therapy. Evaluation of erosion lesions histological quality of healing. Methods Totally 62 cases of gastritis diagnosed as erosive gastritis combined with Helicobacter pylori infection were examined with mucosal tissue. Randomly divided into observation group and control group, in the use of omeprazole, amoxicillin, clarithromycin, the observation group plus epoca was sodium 4 weeks, the control group with sucralfate for 4 weeks, the end of treatment After examination of gastroscopy to determine the quality of the erosion of the lesion and 14C-urea breath test to determine Helicobacter pylori clearance, gastroscopy at the equivalent of the original material taken mucosa tissue, the two groups of patients treated with mucosal inflammatory cell infiltration and mucosal morphology Structural aspects of the histological recovery. Results The healing rate of erosion and Helicobacter pylori in both groups were similar (p> 0.05). The healing quality of gastric mucosa in the treatment group was better than that in the control group (p <0.001). Conclusions Icarotene has a good mucosal protective effect, which can enhance the histological quality of mucosal healing.