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目的了解南京市孕妇孕早期血清中性激素结合球蛋白(SHBG)的平均水平,并探讨SHBG水平与糖脂代谢异常的关系。方法测量105名22~36岁的初产妇孕早期血清中SHBG,孕中期总胆固醇(CHOL)、甘油三脂(TG)、空腹血糖(FPG)、糖化血红蛋白(HA1c)等糖脂代谢指标;记录孕妇的年龄、孕周、孕前身高体重、及产前体重。结果孕早期血清中SHBG为277.75±85.56nmol/L(98.0~454.0nmol/L),P50为284.9nmol/L。SHBG水平孕妇孕周差异无统计学意义,与年龄,孕前体重,与孕期体重增加有相关性,孕早期SHBG与孕中期空腹血糖,餐后两小时糖,糖化血红蛋白,果糖胺等糖代谢指标呈负相关性。与孕中期血清中总胆固醇,甘油三酯,低密度脂蛋白(L-LDL)相关性成负相关,与高密度脂蛋白(H-LDL)呈正相关。结论南京市孕妇孕早期SHBG平均水平为277.75±85.56 nmol/L。早期SHBG水平可能是参与孕期孕妇糖脂代谢紊乱的影响因素。
Objective To understand the average serum levels of sex hormone binding globulin (SHBG) in pregnant women in Nanjing and to investigate the relationship between SHBG levels and abnormal glucose and lipid metabolism. Methods The indexes of blood glucose and lipid metabolism of SHBG, CHOL, triglyceride (TG), fasting blood glucose (FPG) and glycosylated hemoglobin (HA1c) in 105 pregnant women between the ages of 22 and 36 years were measured. Pregnant women’s age, gestational age, pre-pregnancy height and weight, and prenatal weight. Results The serum SHBG in early pregnancy was 277.75 ± 85.56nmol / L (98.0 ~ 454.0nmol / L) and P50 was 284.9nmol / L. There was no significant difference in gestational age between SHBG and pregnant women, but with age, body weight before pregnancy and body weight gain during pregnancy. The fasting blood glucose, SHGG and second trimester glucose, glycosylated hemoglobin and fructosamine in SHBG during the first trimester were Negative correlation. And the second trimester serum total cholesterol, triglyceride, low-density lipoprotein (L-LDL) is negatively correlated with high-density lipoprotein (H-LDL) was positively correlated. Conclusion The average level of SHBG in pregnant women in Nanjing was 277.75 ± 85.56 nmol / L in early pregnancy. Early SHBG levels may be involved in pregnant women, glucose and lipid metabolism disorder factors.