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目的:探讨N-酰半胱氨酸(NAC)与维生素C对中、重度肾功能不全患者造影剂肾病(CIN)的预防作用方法:108例中、重度肾功能不全患者随机分为三组,分别接受0.9%氯化钠溶液(对照组,33例),NAC加0.9%氯化钠溶液(NAC组,34例),以及NAC、维生素C加0.9%氯化钠溶液(NAC+维C组,41例)三种预防方案;所有患者均使用碘克沙醇造影剂。记录患者术前24 h与术后24 h～48 h内血清肌酐(SCr)、尿素(UREA)及尿酸(UA)浓度。结果:三组患者术前与术后的SCr、UREA以及UA值比较差异无统计学意义;三组术后的SCr、UREA以及UA值比较,差异无统计学意义;三组患者肾病发生率比较,差异无统计学意义。结论:NAC与维生素C对造影剂肾病无预防作用,但有待进一步证实
Objective: To investigate the preventive effect of N-acylcysteine (NAC) and vitamin C on contrast medium nephropathy (CIN) in patients with moderate and severe renal insufficiency.Methods: 108 patients with moderate and severe renal insufficiency were randomly divided into three groups, They received 0.9% sodium chloride solution (control group, 33 cases), NAC plus 0.9% sodium chloride solution (NAC group, 34 cases) and NAC, vitamin C plus 0.9% sodium chloride solution 41 cases) three kinds of prevention programs; all patients use iodixanol contrast agent. Serum creatinine (SCr), urea (UREA) and uric acid (UA) concentrations were recorded 24 hours before operation and 24 hours to 48 hours after operation. Results: There was no significant difference in preoperative and postoperative SCr, UREA and UA between the three groups. There was no significant difference in the values of SCr, UREA and UA between the three groups after operation ,The difference was not statistically significant. Conclusion: There is no preventive effect of NAC and vitamin C on contrast agent nephropathy, but it needs further confirmation