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以离子液体1-丁基-3-甲基咪唑硫氰酸盐([Bmim]SCN)作为反应原料和反应介质,在室温下与芳甲酰氯、2-氯-5-吡啶甲胺反应一锅法合成了标题化合物,用1HNMR和IR对其结构进行表征,并初步研究了目标化合物的生物活性。结果表明,10.0 mmol芳甲酰氯与2.16 g(11.0 mmol)[Bmim]SCN反应10 min后,产物不需要分离,继续与1.50 g(10.5 mmol)2-氯-5-吡啶甲胺反应20 min,以82.7%～95.6%的收率得到目标化合物。离子液体[Bmim]SCN可以回收利用,重复使用6次目标产物收率无明显降低。初步生物活性试验表明,标题化合物大多数有一定的杀菌和植物生长调节活性。
An ionic liquid, 1-butyl-3-methylimidazolium thiocyanate ([Bmim] SCN) was used as the reaction material and reaction medium, and reacted with aroyl chloride and 2-chloro- The title compound was synthesized and characterized by 1HNMR and IR. The biological activity of the target compound was also studied. The results showed that after the reaction of 10.0 mmol of formyl chloride with 2.16 g (11.0 mmol) of [Bmim] SCN for 10 min, the reaction was continued for 20 min with 1.50 g (10.5 mmol) of 2-chloro- The target compound was obtained in a yield of 82.7% ~ 95.6%. Ionic liquid [Bmim] SCN can be recycled, no significant reduction in the yield of the target product after 6 times of repeated use. Preliminary biological activity tests showed that most of the title compounds have certain bactericidal and plant growth regulatory activities.