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目的 研究血清前降钙素(procalcitonin,PCT)在评估慢性胆囊炎病人是否存在隐匿性的细菌感染中的价值.方法 入院拟行胆囊切除手术病人53例,慢性胆囊炎无临床发作,术前抽血清检测前降钙素原、C-反应蛋白、白细胞计数,术中留取胆汁行细菌培养,比较胆汁细菌培养阳性者和阴性者之间的血清前降钙素的差异.结果 胆汁培养阳性组(23例)的PCT检测值为(4.62 ±5.23) ng/L,阴性组(30例)为(0.27±0.39) ng/L,阳性组较阴性组明显升高,两组比较差异有统计学意义(P＜0.05).结论 PCT对慢性胆囊炎病人的细菌感染有一定的预测价值.“,”Objective To evaluate procalcitonin(PCT) as a biomarker for predicting bacterial infection in patients with chronic cholecystitis.Methods A total of 53 patients with no outbreak but preparing for cholecystectomy were enrolled.Indicators as PCT,C-reactive protein (CRP) and white blood cell count(WBC) were detected preoperatively.Patients were divided into two groups based on the results of bacteria culture from intra-operative bile.The differences of PCT level between bacteria positive group and negative group were analyzed.Results PCT level was obviously higher in the bacteria positive group(23 patients,4.62 ± 5.23 ng/L)as compared to the bacteria negative group(30 patients,0.27 ± 0.39 ng/L).The difference was statistically significant (P ＜ 0.05).Conclusion This study suggests that PCT can be used as a biomarker for diagnosis of chronic cholecystitis complicated with bacterial infection.