【摘 要】
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Since Lancaster et al. (2013) first described the formation of self-or-ganizing cerebral organoids for modeling neurodevelopmental disorders, it became evident
【机 构】
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Institute of Molecular and Cell Biology, A*STAR Research Entities, Singapore, Singapore“,”School of
论文部分内容阅读
Since Lancaster et al. (2013) first described the formation of self-or-ganizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurode-velopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, dif-ferentiating, migrating and self-organizing pools of neural progen-itors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).
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