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本文旨在研究全身应用药物对烧伤局部气管、血管通透性的影响。 方法:用体重300～400g大鼠,腹腔注射戊巴比妥钠麻醉,在气管上部剪一小孔,插入气管套管,喷入100℃热空气致伤,连续15s。仿Saria等(1983)的取组织测定方法,用荧光分光光度计测定气管依文思蓝含量,作为判断气管血管通透性的指标。Winter(1945)已在实验中证明吗啡有抗炎作用。张宝恒等(1986)证实槐果碱(Sophocarpine)对大、小鼠多种急性浸出性炎症都有明显的对抗作用。张向清等(1982)证实东茛菪碱对100℃沸水烫伤的大鼠皮肤水肿形成有明显的抑制作用。故本文初步探讨了吗啡、哌替啶、槐果碱和阿托品对热空气烧伤大鼠气
This article aims to study the systemic application of drugs on the trachea, vascular permeability. Methods: Rats weighing 300-400g were anesthetized by intraperitoneal injection of pentobarbital sodium. A small hole was made in the upper part of the trachea. The tracheal cannula was inserted into the tracheal cannula and sprayed into hot air at 100 ℃ for 15s. Tissue determination of Saria et al. (1983) measured the method, with a fluorescent spectrophotometer Evans blue airway content, as an indicator of tracheal vascular permeability. Winter (1945) has been shown in experiments that morphine has an anti-inflammatory effect. Zhang et al. (1986) demonstrated that Sophocarpine has significant antagonism against various acute leaching inflammation in large and mouse. Zhang Xiang et al (1982) confirmed that scopolamine on 100 ℃ boiling water scalded rat skin edema significantly inhibited. Therefore, this paper preliminary study of morphine, pethidine, sophocarpine and atropine on hot air burn rat gas